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Open access Oct 2026

Treatment Outcomes in Children with Relapsed Acute Lymphoblastic Leukemia Using ALL-REZ BFM 2002 Protocol: Data from a Single-Center Trial

BACKGROUND. Despite considerable therapy success in newly diagnosed pediatric acute lymphoblastic leukemia (ALL), treatment of relapses remains challenging and requires a personalized approach. In the Russian Federation, the treatment of relapsed ALL is based on ALL-REZ BFM 2002, the protocol suggesting a risk-adapted...

N. A. Batmanova, T. Valiev, M. Shervashidze et al. · 0 citations
Open access Aug 2026

Specific features of hematologic tumors in children with hereditary genetic syndromes

Hereditary genetic syndromes are a significant risk factor for development of oncohematological diseases in childhood. Specifically, Down syndrome is associated with a 500-fold increased risk of acute megakaryoblastic leukemia and a 20-fold increased risk of acute lymphoblastic leukemia compared to the general populati...

V. D. Artemova, T. Valiev · 0 citations

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