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T. van Eimeren

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Open access Sep 2026

Dynamic [18F]PI-2620 recording facilitates prediction of β-amyloid positivity and simultaneous staging of tau and neurodegeneration

Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, A/T/N assessment incorporates β-amyloid-PET (A), tau-PET (T), and [18F]FDG-PET (N). We evaluated if dynamic featu...

Johannes S. Gnörich, J. Kusche-Palenga, Agnes Kling et al. · 0 citations
Open access Sep 2026

Resilience mechanisms in Parkinson's disease: a domain-specific conceptual framework.

While nigrostriatal dopaminergic cell loss is the pathological hallmark of Parkinson's disease, it is well-known that dopamine deficiency cannot fully explain the clinical severity or disease progression. Emerging data suggest that resilience, i.e. the brain's capacity to maintain function despite pathology, plays a ke...

M. C. Ruppert-Junck, T. van Eimeren, Kathrin Giehl et al. · 0 citations
Open access Sep 2026

Dopamine-Deficiency-Related Reorganization of the Somatomotor Network in Prodromal and Early Parkinson's Disease.

INTRODUCTION Network attack tolerance (NAT) measures the brain's ability to sustain information flow despite the loss of critical brain regions. In Parkinson's disease (PD), NAT has been linked to cognitive and motor function. However, it remains unclear how dopaminergic degeneration shapes NAT, and whether it relates...

Adrian L. Asendorf, Verena Dzialas, T. van Eimeren et al. · 0 citations

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