Author

T. Walz

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Open access Sep 2026

The MscS channel from Corynebacterium glutamicum uses a non-canonical gating mechanism

The function and gating mechanism of Escherichia coli mechanosensitive channel of small conductance (EcMscS) is well understood, but it is unknown whether MscS homologs in other bacteria function the same way. Here, we show that the MscS homolog from Corynebacterium glutamicum (CgMscS) opens at a much higher membrane t...

Y. Nakayama, Giorgos Hiotis, T. Walz · bioRxiv · 0 citations

Review Open access Sep 2026

The diverse gating mechanisms of bacterial MscS-like ion channels

Abstract Bacterial mechanosensitive (MS) channels protect cells against hypoosmotic shock by opening, in response to increased membrane tension, a transmembrane pore that allows rapid efflux of osmolytes. The MS channel of small conductance (MscS) in Escherichia coli has been extensively characterized both functionally...

Giorgos Hiotis, Y. Nakayama, Swati Yadav et al. · Biochemical Society Transact... · 0 citations

Open access Jul 2026

The bacterial mechanosensitive channel MscM gates through concerted changes in its transmembrane and cytoplasmic domains

Cryo-electron microscopy is used to reveal the gating mechanism of MscS-like channel EcMscM, showing that the conformations of the transmembrane and cytoplasmic domains are coupled.

Giorgos Hiotis, T. Walz · Nature Communications · 1 citation