Simultaneous determination of belzutifan and cabozantinib, oral agents for renal cell carcinoma, in human plasma using high-performance liquid chromatography.
Belzutifan and cabozantinib are oral drugs for advanced renal cell carcinoma, which display exposure-dependent toxicities. No validated method exists for simultaneously quantifying these drugs in human plasma. In this study, we developed and validated a high-performance liquid chromatography-ultraviolet method for simu...