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Author

Tadamitsu Kishimoto

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Aug 2026

Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation.

This study identified and characterized a conserved allosteric site within the ARID domain that regulates Arid5a-mediated mRNA stabilization and presents Arid5a allosteric inhibition as a promising therapeutic strategy for managing systemic inflammation including sepsis.

Hamza Hanieh, H. Metwally, Tadamitsu Kishimoto · 0 citations

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