Multi-Organ DIA Proteomics Reveals a Shared Xenobiotic Metabolism Stress Program in a Patient-Derived Xenograft Model.
Cancer cachexia is a devastating systemic syndrome characterized by progressive body weight loss and multi-organ dysfunction, yet the proteome-level mechanisms driving synchronized organ remodeling remain incompletely defined. Here, we applied large-scale data-independent acquisition (DIA) proteomics to a reproducible...