Tadeusz W. Inglot

Molecular Characterization of Lasmiditan Binding to Human Serum Albumin: Site Preference, Structural Response, and Binding Energetics

Human serum albumin (HSA), the major transport protein in blood plasma, can substantially influence the distribution of therapeutic compounds. Although lasmiditan (LASMI) is a recently introduced antimigraine drug with reported moderate plasma protein binding, the molecular determinants of its association with HSA re...