Author

Tae-Hwi Schwantes-An

2 papers indexed here

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Open access Sep 2026

Role of IFNL4 Genotype in Hepatic Inflammation and Fibrosis due to Metabolic Dysfunction-Associated Steatotic Liver Disease

Background and Aims: In patients infected with hepatitis C virus, genetic polymorphisms within or near the interferon lambda 4 gene (IFNL4) predict the risk of hepatic inflammation and fibrosis. Several studies have reported that these polymorphisms are also associated with inflammation and fibrosis in patients with fa...

Callie J. Zaborenko, Aaron Hakim, Tae-Hwi Schwantes-An et al. · Research Square · 0 citations

Review Open access Sep 2026

Causal relationship between liver fat reduction and clinical outcomes in human genetic studies and randomized clinical trials of metabolic-dysfunction associated steatohepatitis

Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not recognized as a surrogate endpoint by health authorities. He...

N. Verweij, G. Hindy, Q. Nguyen et al. · medRxiv · 0 citations