Author

Tai-Hong Liu

2 papers indexed here

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Open access Oct 2026

Iterative Optimization of Photoactivatable BRD4 Degraders for Aging-Amplified Immunotherapy in Patient-Derived Lung Cancer Organoids.

Cancer remains a major global health threat. Targeted protein degradation (TPD) has revolutionized the modulation of protein function in therapeutic development. Nevertheless, the design of current TPD agents continues to face challenges, including hook effects and, more critically, the frequent lack of spatial and tem...

Jin-Rong Yang, Fa Wang, Shu-Fei Li et al. · Angewandte Chemie · 0 citations

Sep 2026

Lysosome-Targeted Iridium(III) Photosensitizers Activate the Mitophagy−Ferroptosis Axis to Boost Two-Photon Photoimmunotherapy Against Hypoxic Cisplatin-Resistant Tumors

A hypoxia-tolerant dinuclear photosensitizer that couples two-photon PDT to ferroptosis and systemic antitumor immune activation is established.

Hui Jiang, Qiaoshan Lie, Fa Wang et al. · Journal of Medicinal Chemist... · 0 citations