Open access
Sep 2026
Cytotoxic lymphocyte death drives monocyte activation and TNF/IFN-γ synergism in TBK1 deficiency
Combined TNF and JAK inhibition as an effective therapeutic strategy for TBK1 deficiency is supported and cytotoxic lymphocytes are the primary drivers of aberrant cell death through a T cell-myeloid axis dependent on TNF/IFN-γ synergism.
Xu Han, Jialin Dai, Ji-Hong Xiao et al.
· Cell Death & Disease · 0 citations