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Author

Takao Hashiguchi

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Aug 2026

BNT162b2 mRNA Vaccination Activates Spike-Reactive Regulatory T Cells in Humans.

Studies using mouse models of viral infection have shown that viral antigen-reactive regulatory T cells play multiple context-dependent roles, including attenuating the immune response against the pathogen and limiting inflammatory damage. By contrast, evidence for the presence and function of viral antigen-specific Tr...

Naila Shinwari, Xin-Xin Xue, Dong-Yun Lu et al. · 0 citations
Open access Sep 2026

Somatic Hypermutations Enhance Neutralization Breadth of IGHV3‐53/3‐66 Public Antibodies Against SARS‐CoV‐2 Variants

This work assessed whether non‐broadly neutralizing IGHV3‐53/3‐66 antibodies could mature into broadly neutralizing antibodies and found some acquire broad neutralizing activity through accumulation of somatic hypermutations.

Takeo Kuwata, K. Okazaki, Hiroshi Morioka et al. · 0 citations

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