Author

Takashi Saito

2 papers indexed here

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Open access Sep 2026

Stepwise Upregulation of Microglial Genes through the Slow Progression of Amyloid Pathology in Alzheimer's Disease Model Mice.

Examination of microglial gene expression in the brains of AppNL-F knock-in mice reveals a stepwise mode of microglial gene activation under slow amyloid progression and identifies novel genes that may be relevant to the early stages of Alzheimer's disease.

K. Shirotani, Daisuke Hatta, Kaori Watanabe et al. · Biological and Pharmaceutica... · 0 citations

Open access Aug 2026

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice

A chimeric model of AD is generated by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice and highlighting a role for human astrocytes and APOE-dependent astrocyte functions in modulating AD-related pathology.

Joan Cruz-Sesé, Marta Mirón-Alcala, Maria Alfonso-Triguero et al. · Cell Reports · 0 citations