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T. Shimohata

6 papers indexed here

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Review Open access Oct 2026

[Coexistence of progressive supranuclear palsy and idiopathic normal pressure hydrocephalus: pathophysiology and response to shunt surgery].

This review aims to summarize the frequency, pathophysiological features, and therapeutic effectiveness of shunt surgery in cases of coexisting progressive supranuclear palsy (PSP) and idiopathic normal pressure hydrocephalus (iNPH). In this review, we showed that the coexistence of these two disorders is not rare, tha...

Naoki Yamahara, Takayoshi Shimohata · 0 citations
Review Open access Sep 2026

Clinical Characteristics of Japanese Cases of Anti-Metabotropic Glutamate Receptor Type 1 Antibody-Associated Cerebellar Ataxia

Anti-metabotropic glutamate receptor type 1 (mGluR1) antibody-associated cerebellar ataxia is a rare autoimmune cerebellar ataxia. Although its clinical spectrum has been recognized mainly from Western cohorts, its features in other populations remain uncharacterized. We investigated the clinical characteristics of thi...

N. Yoshikura, Akio Kimura, Akira Takekoshi et al. · 0 citations
Sep 2026

Protocols for Bedside Assessment of Autonomic Dysfunction in Parkinson's Disease and Multiple System Atrophy.

Assessment of autonomic dysfunction is crucial for clinical management of PD and MSA. Autonomic dysfunction can provide important clues for its diagnosis and clinical management. Furthermore, it often progresses over time and significantly affects patients' quality of life. Therefore, it is essential to develop bedside...

Yasuko Mori, Naoki Yamahara, Tomohide Ando et al. · 0 citations
Case report Open access Aug 2026

Bilateral Orbital Fat Hyperintensity in Early Glial Fibrillary Acidic Protein Astrocytopathy

Objectives Glial fibrillary acidic protein (GFAP) astrocytopathy is an inflammatory autoimmune disease of the CNS that targets astrocytes. Although optic disc edema is a frequently reported ocular manifestation in GFAP astrocytopathy, it has not been well-characterized as orbital fat hyperintensity. Here, we report a r...

Yusuke Ito, K. Ohyama, Akio Kimura et al. · 0 citations
Open access Sep 2026

Characteristics and prognostic factors of cognitive impairment in autoimmune glial fibrillary acidic protein astrocytopathy

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a condition that can occasionally cause cognitive impairment (CI). This study aimed to clarify the characteristics of CI in patients with GFAP-A expression and its associated prognostic factors. This retrospective cohort study included patients diagn...

Yasuko Mori, Akira Takekoshi, Yoya Ono et al. · 0 citations
Review Open access Aug 2026

Delayed appearance of bilateral cerebral peduncle lesions in autoimmune glial fibrillary acidic protein astrocytopathy: A serial MRI case series.

Bilateral cerebral peduncle lesions may represent a delayed non-enhancing MRI manifestation of GFAP-A, and careful assessment of the cerebral peduncles on follow-up MRI may help characterize the evolving lesion distribution.

Yusuke Akitomi, Kensuke Takahashi, Yuta Komori et al. · 0 citations

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