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Author

Takayuki Kondo

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2 papers indexed here

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Open access Aug 2026

Base editing rescues a hereditary motor neuron disease in mouse and patient-derived iPSC organoid models

Findings support the therapeutic potential of base editing for hereditary MNDs by identifying the optimal adenine base editor and evaluating the selected editor by subpial delivery of adeno-associated virus (AAV) vectors to the spinal cord.

K. Imamura, Shin Yoshioka, Kota Kamizato et al. · 0 citations
Open access Aug 2026

Generation of mutant human SOD1 knock-in mouse lines at the Rosa26 locus as a platform for developing genome-editing therapies for amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, resulting in progressive paralysis and death within a few years of symptom onset. Although current treatments modestly slow the disease progression, effective disease-modify...

T. Okunomiya, Tomoki Sakasai, Kayoko Tsukita et al. · 0 citations

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