Open access
Jul 2026
Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report.
It is proposed that FFA's effectiveness stems from its ability to address two core pathologies of SV2A deficiency: correction of the excitatory/inhibitory imbalance by restoring inhibitory tone through its serotonergic mechanism, and mitigation of neuroinflammation, thereby stabilizing the neuronal network.
Takayuki Mori, Hiroshi Terashima, Yu Kakimoto et al.
· Epileptic disorders · 0 citations