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Author

Tamer M. Ibrahim

2 papers indexed here

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Open access Oct 2026

Drug repurposing and African natural product screening, targeting the Parkinson‘s-associated LRRK2 G2019S mutant kinase using molecular docking and molecular dynamics approaches

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic contributor to Parkinson’s disease and is associated with increased kinase activity. Targeting this mutation remains a key therapeutic strategy; however, structure-guided identification of repurposable inhibitors remains limited....

Omnia Saeed, Martina B. William, Mohamed Salama et al. · 0 citations
Jul 2026

Identification of novel pyrazolines and isoxazolines as antileishmanial agents via a potential antifolate mechanism: synthesis, biological evaluation, and in silico studies.

Based on its superior potency, high selectivity, and stable target binding in silico, the S-enantiomer of compound 1g represents a promising lead for further antileishmanial development.

Menna Desouky, Menna S. Hany, Ahmed R Elaraby et al. · 0 citations

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