Open access
Oct 2026
cPRIME enables endogenous mapping of genetic variant effects at RNA level
Understanding the functional consequences of genetic variants, particularly those classified as variants of uncertain significance (VUS), is a major challenge in genomics. While variant effects at protein level are well recognized, roles in post-transcriptional regulation are increasingly appreciated. Here, we introduc...
Ghanem El Kassem, Constanze Westphal, Marvin Doebel et al.
· Nature Communications · 0 citations