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Author

Tao Ye

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Open access Sep 2026

Comparison of cell-cycle gene expression dynamics and mRNA kinetics across mouse and human pluripotent systems

Cell-cycle remodeling is fundamental to pluripotency and lineage commitment, yet whether its transcriptional and post-transcriptional architecture is conserved across species and developmental states has remained unresolved. Here we introduce Ciclopes, a biology-informed deep-learning framework that resolves continuous...

Maulik K. Nariya, David Santiago-Algarra, Gianni Zanardelli et al. · 0 citations
Open access Aug 2026

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Findings support p63 as a protumorigenic regulator in FGFR3-mutated tumors despite their luminal differentiation and provide a detailed FGFR3-driven GRN, offering insights into FGFR3-induced oncogenic dependency and potential strategies to circumvent resistance to FGFR inhibitors.

A. Moreno-Vega, M. Zambrano, Lilia Estrada-Virrueta et al. · 0 citations

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