Sulfamethoxazole increases the risk of preeclampsia through PSMB6: A comprehensive multi-omics and experimental validation study.
BACKGROUND Environmental and dietary exposure to sulfamethoxazole (SMX) has been detected in pregnant populations, but its impact on preeclampsia (PE)-related placental pathology-particularly through non-therapeutic chronic exposure-remains poorly understood. METHODS We assessed the effects of maternal SMX exposure o...