BDE-47 and male infertility: integrated network toxicology, single-cell transcriptomics, and in vitro evidence of GSTM1 downregulation and ferroptosis-related molecular remodeling in Leydig cells
Background BDE-47 is a widely detected polybrominated diphenyl ether with potential male reproductive toxicity, but the key testicular cell populations and molecular basis remain unclear. Methods We integrated network toxicology, single-cell transcriptomic data from BDE-47-exposed mouse testes and human idiopathic non-...