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Open access Sep 2026

BDE-47 and male infertility: integrated network toxicology, single-cell transcriptomics, and in vitro evidence of GSTM1 downregulation and ferroptosis-related molecular remodeling in Leydig cells

Background BDE-47 is a widely detected polybrominated diphenyl ether with potential male reproductive toxicity, but the key testicular cell populations and molecular basis remain unclear. Methods We integrated network toxicology, single-cell transcriptomic data from BDE-47-exposed mouse testes and human idiopathic non-...

Xin-Yao Zhu, Shuang Wang, Tao Li et al. · 0 citations
Open access Sep 2026

Integrative network toxicology analysis reveals mechanistic links between PFOA exposure and male reproductive dysfunction

To systematically investigate the molecular mechanisms linking perfluorooctanoic acid (PFOA) to male reproductive health outcomes within a network toxicology framework, and to compare shared pathways across erectile dysfunction (ED), male infertility, and testicular dysfunction. PFOA associated targets were identified...

Tao Zhou, Xin-Yu Zhang, Jing-Hong Yang et al. · 0 citations

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