Author

Tao Zhu

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Open access Aug 2026

PD-L1 upregulated by IGF1R via the PI3K/AKT/NF-κB axis induces sorafenib resistance in hepatocellular carcinoma.

IGF1R upregulates PD-L1 via the PI3K/AKT/NF-κB axis through direct NF-κB-mediated transcriptional activation, and PD-L1 serves as a critical downstream effector driving sorafenib resistance in HCC.

Tao Zhu, Chunmei Xie, Qianqian Shao et al. · Molecular Immunology · 0 citations