Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.
It is demonstrated that pharmacological inhibition of calpain and protein kinase C attenuates psoriatic inflammation and epidermal dysregulation and is associated with modulation of exosome-associated markers and pathways, together with differential regulation of endoplasmic reticulum stress and cytoskeletal networks.