AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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This approach identified Polo-like kinase 1 (PLK1) as a therapeutic vulnerability in fibrolamellar carcinoma, an ultra-rare liver cancer driven by the DNAJB1-PRKACA fusion, illustrating how functional and computational approaches can uncover actionable dependencies in rare cancers.
Using this integrated platform, novel and potentially actionable therapeutic vulnerabilities across multiple rare cancers are identified, including sensitivity to CDK4/6 inhibition in rare bladder cancer, PLK1 inhibition in fibrolamellar carcinoma, and synergistic targeting of MEK and YAP signaling in solitary fibrous...
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