Author

Tatjana Srdić-Rajić

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Open access 2026

4-aminoquinolines promote redox-dependent ferroptosis sensitization in pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer marked by oxidative stress, metabolic rewiring, and resistance to cell death. Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, represents a promising therapeutic vulnerability in PDAC; however, intrinsic resistance to...

M. Zivanovic, Ljubodrag Aleksić, Milica Selaković et al. · Journal of the Serbian Chemi... · 0 citations

Review Open access Aug 2026

Metabolic alterations and redox homeostasis in ferroptosis: emerging mechanisms and therapeutic implications

This review focuses on recent findings of perturbed metabolic processes in cancer that create a high iron demand and an altered lipid composition, thereby predisposing cells to ferroptosis and the therapeutic potential of pharmacological agents that can selectively trigger ferroptosis in tumor cells.

Mirjana Macvanin, D. Spasić, S. Gluščević et al. · Archives of medical science... · 0 citations

Open access Jul 2026

Exploring the therapeutic potential of NCX1 in hematological cancers; integration of molecular docking, bioinformatics approaches, and experimental validation.

Findings have demonstrated NCX1 as a biologically informative marker of myeloid differentiation and a promising therapeutic weak point within calcium signaling networks in hematological malignancies, providing a rationale for future functional and single-cell validation studies.

Sema Mısır, S. Yaman, Nina Petrović et al. · Biochemical and Biophysical... · 0 citations