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Tatsuki Hori

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Open access Oct 2026

RGI-Toolkit: Differentiable Restraints for Controllable Biomolecular Structure Prediction

Diffusion-based models have substantially advanced biomolecular structure prediction. Within this framework, restraint-guided inference (RGI) corrects the denoiser output at each reverse-diffusion step using a differentiable restraint loss, allowing available experimental information, stereochemical requirements, or a...

Tatsuki Hori, Yoshitaka Moriwaki, Ryuichiro Ishitani · 0 citations
Oct 2026

ESCAPE enables receptor-specific chemogenetic dissection of GPCR signaling.

G-protein-coupled receptors (GPCRs) are essential mediators of cellular processes, and their dysfunction is implicated in various diseases. Although pharmacological approaches are powerful for elucidating GPCR functions, careful consideration of potential off-target effects remains crucial. Here, we present an off-targ...

Yuma Matsuoka, Hajime Inoue, Tatsuki Hori et al. · 0 citations

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