Author

Taylor Pio

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Open access Oct 2026

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signatures.

Oligodendrocytes play essential roles in central nervous system development and homeostasis, and their dysfunction is a hallmark of numerous neurological disorders. However, human in vitro systems that support oligodendrocyte lineage progression while enabling the study of disease-relevant states remain limited. Here,...

Taylor Pio, Meghna Bettaiah, Rui Zhao et al. · Stem Cell Reports · 0 citations

Open access Oct 2026

Temporal RNA splicing dysregulation in a human multicellular model of C9orf72 ALS

Amyotrophic lateral sclerosis (ALS) is a complex and heterogenous disease, comprising of familial and sporadic forms, numerous genetic mutations, and a wide range of affected cell types and proposed dysregulated processes. While the usage of in vitro cell cultures, mouse models, and postmortem patient tissue have advan...

Berna Aliya, Shi-Qi Liu, Allison N. Mansfield et al. · bioRxiv · 0 citations