Isoxazoles are versatile N,O-containing five-membered heterocyclic building blocks widely utilized in the construction of chiral pharmaceutical intermediates. Over the past two decades, tremendous progress has been made in their catalytic asymmetric transformations, which can be categorized into three types: organocata...
Lu-Yao Li, Teck-Peng Loh· Chemical Communications· 0 citations
Primary amine-targeted bioconjugation connects proteins and other biomacromolecules with functional payloads for diagnosis and targeted therapy. However, conventional reagents such as N-hydroxysuccinimide esters often modify multiple surface lysines, producing heterogeneous conjugates with compromised activity and clin...
Cheng-Yu Song, Yao-Yao Zhang, Jin-Ling Li et al.· Synlett : Accounts and Rapid...· 0 citations
Only an estimated 9% of all plastic ever manufactured has been recycled, and the remainder persists in landfills, oceans, and, increasingly, in the human body as micro- and nanoplastics. Closing this loop demands chemistry that goes beyond shredding and remelting. This review surveys the mechanistically distinct strate...
Bo-Han Li, Xiao Wang, X. Kong et al.· Sustainable Science and Inno...· 0 citations
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