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Author

Teh-Ying Chou

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Review Oct 2026

Cell-free DNA fragmentomics: from chromatin biology to clinical stratification.

Plasma cell-free DNA (cfDNA) is fragmented nonrandomly, reflecting the chromatin architecture of its source cells and the nucleases that process it. The fragmentome can therefore provide an indirect readout of cellular regulatory state. This review examines how DNA methylation, chromatin accessibility, nucleosome posit...

Tien-Dung Bui, M. Phùng, Teh-Ying Chou et al. · 0 citations
Open access Sep 2026

Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer

This study identifies TXNRD1 as a crucial regulator of cellular plasticity and metastasis in NSCLC via the TGF-β1 pathway, suggesting that targeting TXNRD1 may reduce metastatic potential and improve patient survival.

Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih et al. · 0 citations

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