Review
Open access
Oct 2026
VISTA as a tumour-microenvironment checkpoint: spatial, metabolic and cellular control of antitumour immunity
V-domain immunoglobulin suppressor of T-cell activation (VISTA; also termed VSIR, PD-1H or B7-H5) is increasingly recognised as an immune checkpoint whose biological and clinical significance depends less on total expression than on the tumour microenvironment (TME) in which it operates. Rather than acting as a linear...
Ke-Xun Li, Zi-Long Qian, Jian-Zhe Zhang et al.
· Frontiers in Immunology · 0 citations