Author

Teng-Long Zhang

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Oct 2026

Discovery of Novel Pyridazine-Containing Nicotinamide Derivatives as Potent FTO Inhibitors for Acute Myeloid Leukemia

FTO has been recognized as a promising therapeutic target for acute myeloid leukemia (AML). However, the development of FTO inhibitors with anti-leukemia effects was still limited. Here, based on reasonable design and SAR, a total of 67 compounds were synthesized, among which compound E6 exhibited the strongest activ...

Yu-Meng Wang, Ya-Ting Lu, Hao-Dong Liu et al. · Journal of Medicinal Chemist... · 0 citations

Open access Sep 2026

Lenalidomide triggers ferroptosis in multiple myeloma by blocking the c-Maf/USP7 signaling pathway to induce the ubiquitination and degradation of FTH1.

Multiple myeloma (MM) is the second most common hematological malignancy. Ferroptosis, a distinct form of programmed cell death, has attracted the interest of researchers because of its unique role and biological significance across various diseases. As a first-line clinical treatment drug for MM, lenalidomide (LEN) ha...

Erhao Zhang, Ting-Ting Zhang, Jin-Jin Xu et al. · Cellular Signalling · 0 citations