Sep 2026
TIGIT regulates CD8+T cell exhaustion via the PI3K/AKT-FOXO1-TOX axis in extrahepatic cholangiocarcinoma.
Extrahepatic cholangiocarcinoma (ECCA) is an aggressive malignancy with poor prognosis and few treatment options, partly due to CD8+T cell exhaustion in the tumor microenvironment. The role of TIGIT in driving this process remains mechanistically unclear. Using patient-derived immunocompetent cultures (iPDCs), we show...
Rui-Heng Luo, Ling Li, De-Hong Tan et al.
· Clinical Immunology · 0 citations