Author

Teresia Chen

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Open access Aug 2026

Improved cross-presentation enabled by fusion-dependent mini-proteins that efficiently reach the dendritic cell cytosol

It is shown that substantive improvements in cytosolic antigen delivery provided by the fusion-dependent mini-protein ZF5.3 result in concomitant improvements in MHC-I-mediated antigen presentation and B3Z T-cell activation, which could improve the design of peptide vaccines for immunotherapy.

Teresia Chen, Michel DuPage, Alanna Schepartz · bioRxiv · 0 citations