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Teruaki Yamaguchi

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Open access Sep 2026

Dabrafenib plus trametinib in BRAF V600E-mutant Erdheim-Chester disease: a case series including CNS involvement.

BACKGROUND Erdheim-Chester disease (ECD) is a rare clonal non-Langerhans cell histiocytosis characterized by the infiltration of foamy, CD68-positive/CD1a-negative histiocytes into multiple organ systems. Activating MAPK/ERK pathway mutations, most commonly BRAF V600E, represent common targets for ECD therapies. Althou...

Yuya Kurihara, Akira Honda, Shuhei Matsumoto et al. · 0 citations

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