Author

Tess Lamer

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Open access Sep 2026

Broad-Spectrum, Cell Envelope-Active Marinocyclin Antibiotics From a Coral-Derived Bacterium Are Effective Against Colistin-Resistant Bacteria.

A novel class of lipopeptides with exceptional antibiotic activity, named marinocyclins, isolated from Aquimarina megaterium EL43 associated with the octocoral Eunicella labiata is reported, position marinocyclins as a promising new scaffold for antibiotic development and highlight the potential of Aquimarina spp.

Clara Chepkirui, S. Silva, J. Straetener et al. · Angewandte Chemie · 0 citations

Open access Jul 2026

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

A covalent pan-coronaviral inhibitor that targets 19 Mpros across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses, AVI8122 exhibits low nanomolar potency and favorable pharmacokinetics in mice and is positioned as an early lead compound and a tractable structural starting point for th...

Pu Chen, Ulrike Strunk, E. Arutyunova et al. · Journal of Medicinal Chemist... · 0 citations