Open access
Sep 2026
REN-former prioritizes candidate regulators of kidney disease-state transitions through single-cell foundation modeling and human genetics
Background Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is associated with dynamic changes in tubular cell state. However, conventional single-cell transcriptomic analyses primarily identify genes differentially expressed between disease states and do not directly evaluate genes associated with...
I. Mimura, Sosuke Hosokawa, Y. Hirakawa et al.
· bioRxiv · 0 citations