Thanapon Charoenwongpaiboon

Novel glutaminase-free l-asparaginase from Leuconostoc mesenteroides BN1: biochemical properties, molecular dynamics, and anticancer activity

l-Asparaginase is an essential chemotherapeutic enzyme used to treat acute lymphoblastic leukaemia and certain lymphoid malignancies; however, its clinical use can be limited by adverse effects linked to immunogenicity and undesirable l-glutaminase activity. In this study, a novel glutaminase-free l-asparaginase from L...

A Novel GH26 β-Mannanase from Bacillus subtilis HM7 Producing Manno-Oligosaccharides with Strain-Specific Prebiotic Activity.

SH3-like domains from Leuconostoc citreum ABK-1 alternansucrase enables efficient enzyme immobilization.

Enzyme immobilization is generally used to improve enzyme stability and reusability for industrial applications. In this study, a novel non-covalent immobilization strategy was developed using the SH3-like domains of alternansucrase from Leuconostoc citreum ABK-1 (LcAlts). SH3-like domains contain hydrophobic surface,...