Open access
Oct 2026
Neutralization of the PTX3/CD44 axis suppresses TGF-β1 signaling in kidney fibrosis.
Renal fibrosis is a hallmark of chronic kidney disease (CKD), but effective antifibrotic therapies are lacking. Pentraxin 3 (PTX3) is markedly upregulated in CKD patients and in a unilateral ureteral obstruction (UUO) model, correlating with renal injury, extracellular matrix accumulation, partial epithelial-mesenchyma...
Chao-Chun Cheng, Shen-Shin Chang, Feng-Ping Chen et al.
· FEBS Letters · 0 citations