The Thanh Ngo

Design, Synthesis, and In Vitro Evaluation of Pinostrobin-Based Hydrazones as Potent α-Glucosidase Inhibitors

Twenty-four pinostrobin hydrazone derivatives (TN01–TN24) were synthesized through two continuous steps from pinostrobin, hydrazone, and aldehyde derivatives, well characterized and screened for inhibitory activity against yeast α-glucosidase (Saccharomyces cerevisiae). To further expand the chemical space, a QSAR-gu...