Open access
Oct 2026
Development of a nanomedicine approach to improve the therapeutic index of bexarotene
Bexarotene (BEX), a retinoid X receptor (RXR) agonist, has demonstrated therapeutic potential in oncology, neurodegenerative diseases and inflammatory conditions, including multiple sclerosis (MS). However, its broader clinical application is limited by poor aqueous solubility, low bioavailability, and dose-limiting ad...
Siân Rizzo, Carola Pepe, Thibault Albert et al.
· bioRxiv · 0 citations