Author

Theodore M. Kamenecka

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Open access Jul 2026

Rational design of RORγT small molecule modulators results in tunable LXRα pleiotropic effects in Th17 cells 2267479

Rational design of small molecule modulators enhanced RORγT inverse agonism and tuned LXRα agonism enhanced RORγT inverse agonism and tuned LXRα agonism better suppressed the pathogenic Th17 phenotype, reducing IL-17 secretion and downstream gene expression.

Matthew D. Mann, M. Chang, Vuong Q. Dang et al. · Journal of Immunology · 0 citations