Author

Thi Kim Oanh Nguyen

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Open access Sep 2026

Discovery and preclinical validation of a translationally optimized mitochondrial complex I modulator for Alzheimer’s disease

Findings establish mild modulation of mtCI as a therapeutic strategy to restore metabolic resilience and identify C273 as a promising disease-modifying candidate for AD treatment.

Sergey Trushin, Thi Kim Oanh Nguyen, Mark Ostroot et al. · npj Drug Discovery · 0 citations

Open access Aug 2026

Multilevel impairment of mitochondrial respiration in inclusion body myositis.

Oxidative phosphorylation (OXPHOS) is a central function and a key indicator of mitochondrial fitness, yet studies in human tissue remain limited. Inclusion body myositis (IBM) is a progressive myopathy that lies at the intersection of aging, inflammation and mitochondrial dysfunction. We aimed to perform a comprehensi...

Ibrahim Shammas, Hazem Iaali, J. Watzlawik et al. · Brain : a journal of neurolo... · 0 citations