Thiyagamurthy Pandurangan

Abstract A053: Discovery and modular design of CDK12–DDB1 molecular glues for targeted Cyclin K degradation

Advanced lead molecules across these series achieve a rare combination of high CDK12/13 selectivity, potent and durable cyclin K degradation, and favorable physicochemical, in vitro ADME, and in vivo PK properties, supporting progression toward IND-enabling preclinical safety evaluation.