The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of a variety of lipids (including cationic) in high amounts to form complexes with the negatively charged RNA. While this approach was successful for t...
Johannes Singer, Kathrin Halter, Chun-Yin Chan et al.· Angewandte Chemie· 0 citations
Selective modification of methylated bases in RNA and DNA is central to the field of epigenetics and furthermore fundamental for developing next-generation sequencing and liquid biopsy applications. While in DNA the detection and modification of 5-methylcytidine (5mdC) is fairly advanced, current strategies for detecti...
Kora Holschbach, T. Walter, Davide Guglielminotti et al.· RSC Chemical Biology· 0 citations
Cross-linking mass spectrometry (XL-MS) has advanced as a powerful approach to map protein-protein interactions in cells. With recent advances in cross-linkers, instrumentation, and software, interactions can be observed in a proteome-wide fashion at residue-level resolution. In most XL-MS experiments, a chemical cross...
Piyoosh Sharma, Divya Yadav, Anneliese M. Faustino et al.· Journal of Proteome Research· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.