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Author

Thomas Kodadek

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Open access Jul 2026

Discovery of Non-Inhibitory Macrocyclic Ligands for Protein Tyrosine Phosphatase 1B Using a Function-Based, Iterative Screening Strategy

Chemically induced proximity is a powerful modality for manipulating protein function. Most of the effort in this field has focused on targeted protein degradation but recruitment of other types of post-translational modification enzymes to a target protein is also of interest. To construct such reagents, one would ide...

Jia-Jun Dong, Bo Li, Chung-Wei Fu et al. · 0 citations
Open access Jul 2026

Discovery of low molecular weight protein-binding fragments from bead-displayed libraries: application to monomeric proteins

Various strategies to multimerize monomeric targets are explored, thus allowing them to be used as targets in this fragment discovery platform and a particularly effective and convenient strategy is to express a fusion of the POI with FOLDON, a 30-residue, homo-trimeric peptide.

Joel Tong, Isuru M. Jayalath, James V. Parsons et al. · 0 citations

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