Here, we conduct a large meta-analysis of DNA methylation across multiple cortical brain regions, in relation to increasing burden of Lewy body pathology. Utilizing a dataset of 1205 samples (832 unique donors), we identify 24 false discovery rate significant differentially methylated loci associated with Lewy body...
Joshua Harvey, J. Imm, Morteza Kouhsar et al.· Nature Communications· 0 citations
This study is the first to validate several synaptic markers in human post-mortem-associated GBA N370S mutation suggesting the potential role of GBA gene due to mutations which could alter the levels of some synaptic markers.
Thamir M. Eid, T. Lashley, Thomas T. Warner et al.· Brain Communications· 0 citations
Young onset, less parkinsonism and more cognitive and cortical sensory impairment, along with reduced MRI parietal volumes point to CBS-AD, while limb dystonia, falls and worse verbal fluency relate to CBS-non-AD.
D. Vaughan, M. T. Jensen, R. Real et al.· Brain : a journal of neurolo...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.