Author

Thouis R. Jones

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Open access Aug 2026

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes

This study establishes large-scale adipocyte cell villages as a powerful and generalizable framework to map the context-dependent regulatory architecture of cardiometabolic disease and provides a resource linking human genetic variation to adipocyte cellular programs.

Yi Huang, Joaquin Perez-Schindler, Sanchari Datta et al. · bioRxiv · 0 citations

Open access Aug 2026

Mapping enhancer–gene regulatory interactions from single-cell data

A family of classification models, scE2G, is introduced that predict enhancer–gene regulatory interactions from single-cell datasets and enable mapping of these interactions across diverse cell types and tissues and will enable accurate mapping of enhancer–gene regulatory interactions across thousands of human cell typ...

Maya U. Sheth, Wei-Lin Qiu, X. Ma et al. · Nature Genetics · 1 citation