Open access
Oct 2026
TIA1 is required for microglial activation in tauopathy.
The RNA-binding protein T cell intracellular antigen-1 (TIA1) regulates cellular stress responses and tau pathology, key contributors to the pathophysiology of tauopathies, including Alzheimer's disease (AD). TIA1 acts in peripheral monocytes to inhibit inflammation, but its function in central microglia, critical to n...
C. J. Webber, S. V. D. van der Spek, A. L. Cruz et al.
· Cell Reports · 0 citations