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Open access Aug 2026

Identification of interleukin-11 as a comorbid risk factor for prostate cancer and Alzheimer’s disease using integrated bioinformatics and machine learning

Background Prostate cancer (PCa) and Alzheimer’s disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options. Identifying shared molecular drivers may reveal new treatment targets. Objective To identify common transcriptomic signatures between PCa and AD and validat...

Meng-Xue Wang, Yan-Rong Qian, En-Yao Huang et al. · 0 citations
Open access Aug 2026

Linoleic acid metabolic reprogramming is linked to immunometabolic remodeling and post-transplant recurrence risk in hepatocellular carcinoma

Multi-omics analyses indicate that, in primary pre-transplant HCC, post-transplant recurrence is associated with an imbalance between a higher estimated Δ6-desaturation index and attenuated oxidative catabolism-related features of linoleic acid, accompanied by Treg-associated immunosuppressive remodeling.

Ruixin Zhang, Anhong Zhang, Tian Gao et al. · 0 citations

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