Glioblastoma (GBM) is a highly aggressive malignancy with a poor prognosis. Despite advanced molecular characterization, the traditional tumor-centric model ignores the patient’s systemic body condition, which significantly influences disease progression and therapeutic outcomes. This review aims to elucidate the inter...
Tian-Qing Zhang, Yuan Guo, Qian Yu et al.· Frontiers in Oncology· 0 citations
High expression of NR4A1 inhibits glycolysis in macrophages by activating the Wnt/β-catenin pathway, thereby affecting cardiomyocyte apoptosis mediated by M1 macrophage polarization.
Bo Sun, Yin-Huan Lu, Meng-Yuan Chen et al.· Journal of Inflammation Rese...· 0 citations
A comprehensive overview of multi-level therapeutic strategies directed against the NLRP3 inflammasome is provided, critically evaluates preclinical and clinical evidence—including findings from the CANTOS trial—and discusses the translational potential of NLRP3-targeted immunometabolic therapy in CVDs.
Tian-Qing Zhang, Li Luo, Kai-Lin Yang et al.· Frontiers in Immunology· 1 citation
These findings establish gliadin-fucoidan macromolecular assembly as a pH-responsive and biologically functional oral nanoplatform for renal inflammation.
Bo Sun, Yuan Zhuang, Wu-Yan Qian et al.· International Journal of Bio...· 0 citations
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