Open access
Sep 2026
Macrophage Mistargeting During Direct Cardiac Reprogramming: Cardiac-Associated Responses, Polarization, and Cell Death
Background/Objectives: In situ reprogramming of cardiac fibroblasts into induced cardiomyocytes (iCMs) holds great promise for myocardial infarction (MI) therapy by replenishing lost cardiomyocytes. A transcription factor cocktail consisting of Mef2c, Gata4, and Tbx5 (MGT) represents a widely used starting regimen for...
Ting-Zhen Chen, Shan-Shan Ding, Zhong-Wen Zhang et al.
· Biomedicines · 0 citations